Prevention & lipidsCohort study
Non-HDL cholesterol and residual cardiovascular risk in statin-treated patients with and without diabetes: the Western Denmark Heart Registry
- Cohort study
- registry-based
Authors' conclusion
In statin-treated IHD patients with and without diabetes, non-HDL-C, especially above the 75th percentile, is associated with residual cardiovascular risk.
Study context
- Population
- Statin-treated ischaemic heart disease (IHD) patients with and without DM examined by coronary angiography, Western Denmark Heart Registry, 2011–20208,196 with DM, 33,861 without
- Participants
- 42,057 patients
- Exposure
- Non-HDL-C percentiles vs non-HDL-C <25th percentile
- Outcome
- ASCVD (MI, ischaemic stroke, CV death) and all-cause death
- Follow-up
- Median 4.6 years
Main finding
As reported in the abstract
ASCVD · median 4.6 years
Each group vs <25th percentileAdjusted hazard ratio (CI)
25th-74thwith DM
1.0(0.9–1.2)
75th-94thwith DM
1.3(1.1–1.6)
≥95thwith DM
1.6(1.2–2.1)
25th-74thwithout DM
1.1(0.9–1.1)
75th-94thwithout DM
1.2(1.1–1.4)
≥95thwithout DM
1.7(1.4–2.0)
Observational data: associations, not effects.
Further findings
Atherosclerotic cardiovascular disease (ASCVD) event rate per 1000 person-years, by DM status · median 4.6 years
- With DM
- 28.8 (27.1-30.5)
- Without DM
- 17.2 (16.5-17.8)
ASCVD across sex, age, clinical presentation and LDL-C strata
- Results consistent across strata
Original publication
Non-HDL cholesterol and residual cardiovascular risk in statin-treated patients with and without diabetes: the Western Denmark Heart Registry. Eur J Prev Cardiol. Published 21 March 2024. doi:10.1093/eurjpc/zwae119
Summarised from the published abstract; every number is checked against it