Prevention & lipidsMeta-analysis
Non–High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events
- Pooled analysis of prospective cohort studies (individual participant data)
- 6 prospective cohorts
- US and Finland
Authors' conclusion
Individuals with persistent non-HDL-C dyslipidemia from childhood to adulthood had an increased risk of CVD events, but those in whom dyslipidemic non-HDL-C levels resolve by adulthood have similar risk to individuals who were never dyslipidemic.
Study context
- Population
- Children (mean age at baseline 10.7 years) in 6 cohorts in the US and Finland, recruited 1970–1996, followed to 2019147 cardiovascular disease (CVD) events
- Participants
- 5,121 children
- Comparison
- Non-HDL-C status from childhood to adulthood
- Outcome
- Incident fatal and nonfatal CVD events adjudicated by medical records
- Follow-up
- Mean 8.9 years after age 40 years
Pooled result
As reported in the abstract
CVD events by childhood-to-adulthood non-HDL-C status
Hazard ratio (95% CI)
Incident dyslipidemia vs Normal
2.17(1.00–4.69)
Persistent dyslipidemia vs Normal
5.17(2.80–9.56)
Resolved dyslipidemia vs Normalnot significantly increased
1.13(0.50–2.56)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD events per 1-unit increase in non-HDL-C z score — Childhood non-HDL-C z score | 1.42 (1.18–1.70) | |
| CVD events per 1-unit increase in non-HDL-C z score — Adult non-HDL-C z score | 1.50 (1.26–1.78) | |
| CVD events per 1-unit increase in non-HDL-C z score — Childhood non-HDL-C z score, adjusted for adult levels | 1.12 (0.89–1.41) | |
| 0.512Hazard ratio (log scale) |
CVD events per 1-unit increase in non-HDL-C z score
- Childhood non-HDL-C levels and change into adulthood independently associated with outcome (complementary analysis)
Original publication
Non–High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events. JAMA. Published 4 June 2024. doi:10.1001/jama.2024.4819
Summarised from the published abstract; every number is checked against it