Heart failure & cardiomyopathies
Non-invasive assessment of left ventricular activation delay for identifying cardiac resynchronization therapy responders using ultra-high-frequency electrocardiogram
Authors' conclusion
UHF-ECG enables non-invasive assessment of QLV and can help with identification of patients who will benefit from CRT.
Study context
- Population
- CRT candidates undergoing biventricular CRTpatients included
- Participants
- 48 candidates
- Comparison
- non-invasive assessment of left ventricular (LV) delay using ultra-high-frequency electrocardiogram (UHF-ECG) with invasive QLV in CRT candidates
Main finding
As reported in the abstract
Agreement of UHF-ECG in V8, V7, and V6 with QLV in the basal, midventricular, or apical segments
Mean difference V8 vs basal
3 ± 14 ms, P = .52
Mean difference V7 vs midventricular
−3 ± 17 ms, P = .18
Mean difference V6 vs apical
0 ± 17 ms, P = .92
Correlation
r = 0.84, P < .001
Further findings
| Outcome | UHF-ECG LV delay | QLV | Baseline lv-DYS >58 ms | Shorter lv-DYS | |
|---|---|---|---|---|---|
| Reduction in lv-DYS and CRT response by baseline lv-DYS | |||||
| Δlv-DYS | Not reported in the abstract | Not reported in the abstract | −70 ms | −8 ms | UHF-ECG LV delay, QLV: not reported in the abstract |
| Responders | Not reported in the abstract | Not reported in the abstract | 97% | 32% | UHF-ECG LV delay, QLV: not reported in the abstract |
Correlation of LV dyssynchrony (lv-DYS) with the longest QLV
- Correlation
- r = 0.76, P < .001
Original publication
Non-invasive assessment of left ventricular activation delay for identifying cardiac resynchronization therapy responders using ultra-high-frequency electrocardiogram. Heart Rhythm. Published 10 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it