Heart failure & cardiomyopathiesResearch article
Non-invasive assessment of left ventricular activation delay for identifying cardiac resynchronization therapy responders using ultra-high-frequency electrocardiogram
- Consecutive patients undergoing cardiac resynchronization therapy (CRT) at 2 centers
Authors' conclusion
UHF-ECG enables non-invasive assessment of QLV and can help with identification of patients who will benefit from CRT.
Study context
- Population
- CRT candidates undergoing biventricular CRTpatients included
- Participants
- 48 candidates
- Comparison
- non-invasive assessment of left ventricular (LV) delay using ultra-high-frequency electrocardiogram (UHF-ECG) with invasive QLV in CRT candidates
Main finding
As reported in the abstract
Agreement of UHF-ECG in V8, V7, and V6 with QLV in the basal, midventricular, or apical segments
mean difference V8 vs basal
3 ± 14 ms, P = .52
mean difference V7 vs midventricular
−3 ± 17 ms, P = .18
mean difference V6 vs apical
0 ± 17 ms, P = .92
correlation
r = 0.84, P < .001
Further findings
| Outcome | UHF-ECG LV delay | QLV | baseline lv-DYS >58 ms | shorter lv-DYS |
|---|---|---|---|---|
| Reduction in lv-DYS and CRT response by baseline lv-DYS | ||||
| Δlv-DYS | Not reported in the abstract | Not reported in the abstract | −70 ms | −8 ms |
| responders | Not reported in the abstract | Not reported in the abstract | 97% | 32% |
Correlation of LV dyssynchrony (lv-DYS) with the longest QLV
- correlation
- r = 0.76, P < .001
Original publication
Non-invasive assessment of left ventricular activation delay for identifying cardiac resynchronization therapy responders using ultra-high-frequency electrocardiogram. Heart Rhythm. Published 10 March 2026. doi:10.1016/j.hrthm.2026.03.005
Summarised from the published abstract; every number is checked against it