Arrhythmias & electrophysiologySecondary analysis
Non-invasive cardiovascular magnetic resonance pulmonary capillary wedge pressure predicts future atrial fibrillation: a LOOP substudy
- LOOP substudy
Authors' conclusion
Elevated CMR-PCWP is associated with AF in older, high-stroke-risk individuals, underscoring the role of subclinical diastolic dysfunction in promoting arrhythmogenesis. Incorporating non-invasive PCWP assessment into routine CMR evaluation may enhance risk stratification, allowing prompt identification of at-risk patients and enabling earlier, precise, targeted measures for AF prevention.
Study context
- Population
- Older, high-stroke-risk participants from the LOOP study, each receiving implantable loop recorder for continuous rhythm monitoringparticipants enrolled from the LOOP study
- Participants
- 202 participants
- Comparison
- Cardiovascular magnetic resonance (CMR)-derived pulmonary capillary wedge pressure (PCWP) as predictor of incident atrial fibrillation (AF)
- Individuals with AFn = Eighty-six
Primary result
As reported in the abstract
Participants who manifested AF during follow-up
Eighty-six participants (42.6%)
Further findings
CMR-PCWP in individuals with AF vs without
- CMR-PCWP, AF vs no AF (mmHg)
- 16.1 ± 2.8 vs 14.7 ± 2.3
- Greater left atrial volume (LAV) in individuals with AF
- P < .01
Incident AF by PCWP ≥16 mmHg (univariate regression)
- HR for PCWP ≥16 mmHg
- 2.73
- univariate
Incident AF by PCWP ≥16 mmHg (stepwise Cox regression)
- HR for PCWP ≥16 mmHg
- 2.88
- P < .001
- PCWP ≥16 mmHg and the CHARGE-AF score remained independently associated with AF
Kaplan-Meier probability of AF by PCWP threshold
- Significantly increased probability of arrhythmia over time
Original publication
Summarised from the published abstract; every number is checked against it