Heart failure & cardiomyopathies
Non-invasive diagnosis of transthyretin cardiac amyloidosis utilizing typical late gadolinium enhancement pattern on cardiac magnetic resonance and light chains
Authors' conclusion
The combination of a typical LGE and Look-Locker pattern on CMR with negative light chains is highly specific for ATTR-CA.
Study context
- Population
- Patients with confirmed AL or ATTR cardiac amyloidosis with typical late gadolinium enhancement (LGE) and Look-Locker pattern for cardiac amyloidosis (CA) on cardiac magnetic resonance (CMR)89 ATTR-CA, 58 AL-CA
- Participants
- 147 patients
- Comparison
- Typical CMR LGE and Look-Locker pattern plus negative light chains for diagnosis of ATTR-CA
- Outcome
- Diagnostic accuracy (sensitivity, specificity) for ATTR-CA
Methodological detailsretrospective, 3 academic medical centres
- Retrospective
- 3 academic medical centres
Performance
As reported in the abstract
Diagnosis of ATTR-CA, entire cohort
| Test or model | Sensitivity | Specificity |
|---|---|---|
| CMR and light-chain algorithm | 73% | 98% |
CMR and light-chain algorithm
Sensitivity73%
Specificity98%
Further findings
| Outcome | CMR and light-chain algorithm | Invasive tissue biopsy | |
|---|---|---|---|
| Diagnosis of ATTR-CA, biopsy-confirmed subset | |||
| Sensitivity | 69% | Not reported in the abstract | Invasive tissue biopsy: not reported in the abstract |
| Specificity | 98% | Not reported in the abstract | Invasive tissue biopsy: not reported in the abstract |
Abnormal light-chain biomarkers
- Light-chain biomarkers abnormal
- 81 (55%)
Original publication
Non-invasive diagnosis of transthyretin cardiac amyloidosis utilizing typical late gadolinium enhancement pattern on cardiac magnetic resonance and light chains. Eur Heart J Cardiovasc Imaging. Published 10 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it