Pulmonary vascular disease & thromboembolismCohort study
Non-Invasive Prediction of Pulmonary Vascular Disease-Related Exercise Intolerance and Survival in Non-Group 1 Pulmonary Hypertension
- Prospective cohort study
- multicentre
Authors' conclusion
Non-invasive REVEAL risk predicts mortality in non-group 1 PH without incremental prognostic value from detailed RV function or RV-PA coupling assessment.
Study context
- Population
- Non-group 1 pulmonary hypertension (PH) (group 2, 3, 4 or 5) with pulmonary vascular disease, PVDOMICS cohort449 group 3/4/5
- Exposure
- Group 1 PH risk scores for predicting death
- Outcome
- c-statistic to predict death
Main finding
As reported in the abstract
Prediction of death, group 3/4/5 PH (n = 449)
REVEAL 2.0
0.699
c-statistic · 95% CI 0.660–0.737
REVEAL Lite 2
0.695
c-statistic · 95% CI 0.656–0.734
- French
- c-statistic difference −0.072 (95% CI −0.123 to −0.020); P = 0.006
- COMPERA 2
- c-statistic difference −0.043 (95% CI −0.067 to −0.018); P = 0.0007
Observational data: associations, not effects.
Further findings
Incremental value of RV function and right ventricular-pulmonary artery (RV-PA) coupling over REVEAL
- Prognostic in isolation but no incremental value to REVEAL
- P > 0.50 for all
Prediction of death, group 2 PH
- Findings similar in group 2 PH (n = 239)
REVEAL Lite 2 stratification and PVD phenotype
- Higher risk identified worse exercise capacity, RV-PA uncoupling, ventricular interdependence and impaired cardiac output reserve
- P < 0.05 for all
Original publication
Non-Invasive Prediction of Pulmonary Vascular Disease-Related Exercise Intolerance and Survival in Non-Group 1 Pulmonary Hypertension. Eur J Heart Fail. Published 26 July 2024. doi:10.1002/ejhf.3396
Summarised from the published abstract; every number is checked against it