Coronary disease & ACSResearch article
Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes
- Patients with acute coronary syndromes (ACS) were divided into four groups based on the number of non-modifiable risk factors (NMRFs)
Authors' conclusion
In patients with ACS, the burden of NMRFs was not correlated with OCT-defined plaque vulnerability or the prevalence of plaque rupture, both at culprit and non-culprit lesions. Conversely, a higher number of NMRF was linked to a greater probability of calcified plaque and a lower probability of plaque erosion.
Study context
- Population
- Patients with acute coronary syndromes (ACS), coronary plaque characteristics defined by optical coherence tomography (OCT)plaques analysed · culprit plaques 1,663 · non-culprit plaques 682
- Participants
- 2,345 patients
- Comparison
- correlate the number of NMRFs with coronary plaque characteristics defined by optical coherence tomography (OCT)
Main finding
As reported in the abstract
OCT-defined vulnerable features and plaque rupture in culprit plaques
P-trend for each vulnerable feature
> 0.05
P-trend for plaque rupture
0.856
Further findings
Calcified plaque
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| number of NMRF · directly correlated | 2.60 (2.01–3.37) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Erosion
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| number of NMRF · inversely correlated | 0.72 (0.61–0.84) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Vulnerable features in non-culprit plaques
- no association between the number of NMRFs and vulnerable features
Original publication
Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes. Eur Heart J Cardiovasc Imaging. Published 27 January 2026. doi:10.1093/ehjci/jeag023
Summarised from the published abstract; every number is checked against it