Heart failure & cardiomyopathies
Noninvasive Screening for Elevated Left Ventricular End-diastolic Pressure (LVEDP) and Health Status in Outpatients at Risk for Heart Failure
Authors' conclusion
Nearly 40% of screened patients with HF risk factors had an elevated LVEDP, with over two-thirds reporting significant health status impairment. Combining the KCCQ with noninvasive LVEDP assessments can identify patients who may require further HF evaluation. Future studies should assess the impact of these strategies on patients' subsequent treatment, health status, and clinical events.
Study context
- Population
- Adults with diabetes mellitus, chronic kidney disease (CKD), or suspected heart failure (HF) screened in primary care
- Participants
- 2,040 screened patients
- Comparison
- Noninvasive assessment of LVEDP
- Outcome
- Elevated LVEDP
Methodological detailsconvenience sample, 3 primary care clinics
- Convenience sample
- 3 primary care clinics
Main finding
As reported in the abstract
- Screened patients with elevated LVEDP
- 38.5%
- Older patients, women, and those with CKD more likely to have an elevated LVEDP
- P < 0.01 for all
Further findings
Kansas City Cardiomyopathy Questionnaire Overall Summary (KCCQ-OS) score among patients with a positive screening result
- KCCQ-OS scores collected
- 653
- Mean KCCQ-OS
- 85 ± 20
- KCCQ-OS of 100 (asymptomatic)
- 31.4%
- KCCQ-OS <80, consistent with NYHA functional class II-IV
- 26.5%
Characteristics of screened patients
- Mean age
- 74 ± 8 years
- Women
- 49.8%
- With diabetes mellitus
- 64.6%
- With CKD
- 34.9%
Original publication
Noninvasive Screening for Elevated LVEDP and Health Status in Outpatients at Risk for Heart Failure. JACC Adv. Published 18 July 2025. doi:10.
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