Valvular & structural heart diseaseCohort study
Nonischemic Septal Fibrosis in Functional Tricuspid Regurgitation Provides Incremental Stratification of Adverse Remodeling and Prognosis
- Cohort study
Authors' conclusion
Among patients with advanced TR, NIsF is an important marker of adverse right-sided chamber remodeling and provides incremental prognostic utility beyond conventional risk markers.
Study context
- Population
- Patients with advanced (≥ moderate) functional tricuspid regurgitation (TR) undergoing cardiac magnetic resonance (CMR)29.4% with nonischemic septal fibrosis (NIsF)
- Participants
- 663 patients
- Exposure
- NIsF vs no NIsF
- Outcome
- All-cause mortality
- Follow-up
- Mean 4.3 ± 4.3 years
Main finding
As reported in the abstract
Hazard ratio
1.79
95% CI 1.26–2.56
P = 0.001
NIsF vs No NIsF
HR 1.79 (95% CI 1.26–2.56); P = 0.001
- Kaplan-Meier: significantly higher mortality with NIsF vs without
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | NIsF | No NIsF |
|---|---|---|
| TR regurgitant fraction by NIsF extent | Not reported in the abstract | 34.9% ± 1.5% |
- TR regurgitant fraction by NIsF extent: 1 segment 38.1% ± 13.0%
- TR regurgitant fraction by NIsF extent: 2 segments 40.8% ± 13.8%
- TR regurgitant fraction by NIsF extent: P < 0.001
Adverse chamber remodeling
- NIsF associated with larger LV and right ventricular (RV) volumes, reduced systolic function and increased TR severity
- all P < 0.001
Original publication
Nonischemic Septal Fibrosis in Functional Tricuspid Regurgitation Provides Incremental Stratification of Adverse Remodeling and Prognosis. JACC Cardiovasc Imaging. Published 3 July 2025. doi:10.1016/j.jcmg.2025.03.015
Summarised from the published abstract; every number is checked against it