HypertensionCross-sectional study
Normalization of ascending aorta dimension for body size influences pathophysiologic correlation in hypertensive patients: the Campania Salute Network
- Cross-sectional study
- registry-based (Campania Salute Network)
Authors' conclusion
Among patients with long-standing controlled systemic hypertension, magnitude of aortic remodelling is influenced by the type of the measure adopted, with physiological consistency only for AscAo and AscAo/HT, but not for AscAo/BSA.
Study context
- Population
- Treated hypertensive patients ≥18 years with available ascending aorta ultrasound
- Participants
- 1,634 patients
- Exposure
- Ascending aorta (AscAo) vs AscAo/HT vs AscAo/BSA
- Outcome
- Correlates of AscAo measures with demographics and metabolic profile
Main finding
As reported in the abstract
Obesity and DM associated with greater AscAo and AscAo/HT but smaller AscAo/BSA
P < 0.001
Observational data: associations, not effects.
Further findings
Cardiovascular (CV) events (sensitivity analysis, Kaplan-Meier)
- Only dilated AscAo and AscAo/HT significantly associated with increased risk of CV events
- P < 0.008
Original publication
Normalization of ascending aorta dimension for body size influences pathophysiologic correlation in hypertensive patients: the Campania Salute Network. Eur J Prev Cardiol. Published 6 July 2023. doi:10.1093/eurjpc/zwad224
Summarised from the published abstract; every number is checked against it