Prevention & lipidsCohort study
Normalized creatinine-to-cystatin C ratio and atherosclerotic cardiovascular disease risk in the UK Biobank
- Prospective cohort study
Authors' conclusion
A high NCCR was independently associated with a reduced risk of ASCVD, particularly in females.
Study context
- Population
- UK Biobank participants enrolled 2006–201027,026 developed atherosclerotic cardiovascular disease (ASCVD)
- Participants
- 267,167 participants
- Exposure
- Higher vs lower normalized creatinine-to-cystatin C ratio
- Outcome
- All-cause ASCVD incidence
- Follow-up
- Mean 15 years
Main finding
ASCVD per NCCR
Hazard ratio
0.91
95% CI 0.89–0.92
NCCR
HR 0.91 (95% CI 0.89–0.92)
Per NCCR, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
ASCVD by sex (subgroup)
- Significant negative non-linear association in males; stronger linear association in females
Original publication
Normalized creatinine-to-cystatin C ratio and atherosclerotic cardiovascular disease risk in the UK Biobank. Eur J Prev Cardiol. Published 17 February 2026. doi:10.1093/eurjpc/zwag113
Summarised from the published abstract; every number is checked against it