Heart failure & cardiomyopathies
Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis
Authors' conclusion
Non-obstructive HCM possesses a distinctive flow component distribution pattern characterised by greater direct flow proportions, and direct flow-stroke volume uncoupling indicative of diminished cardiac reserve.
Study context
- Population
- Patients with non-obstructive hypertrophic cardiomyopathy (HCM) and matched controls undergoing 4D-flow CMR
- Participants
- 51 patients
- Exposure
- Non-obstructive HCM vs matched controls
- HCMn = 37
- Controlsn = 14reference
- Outcome
- LV flow component distribution (direct flow, retained inflow, delayed ejection flow, residual volume) and component end-diastolic kinetic energy/mL
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
Direct flow proportion
P = 0.002
Observational data: associations, not effects.
Further findings
Correlations of direct flow proportion
- Left-ventricular (LV) mass index
- r = 0.40, P = 0.004
- End-diastolic volume index
- r = −0.40, P = 0.017
- SCD risk
- r = 0.34, P = 0.039
Stroke volume vs direct flow proportion
- In HCM, unlike controls, stroke volume decreased with increasing direct flow proportions (diminished volumetric reserve)
Original publication
Novel insights into diminished cardiac reserve in non-obstructive hypertrophic cardiomyopathy from four-dimensional flow cardiac magnetic resonance component analysis. Eur Heart J Cardiovasc Imaging. Published 28 April 2023. doi:10.
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