NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?)
Primary result · All-cause mortality and HF readmissionsResult — go to the resultHazard ratio 0.96 95% CI 0.72–1.37Authors' conclusion
The PRIMA II trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?) demonstrates that the guidance of HF therapy to reach an NT-proBNP reduction of >30% after clinical stabilization did not improve 6-month outcomes.
Study context
- Population
- Patients with acute decompensated heart failure (HF) and NT-proBNP >1700 ng/L, randomised after clinical stability
- Participants
- 405 patients
- Comparison
- In-hospital NT-proBNP-guided therapy vs conventional treatment
- Primary endpoint
- Dual: composite of all-cause mortality and HF readmissions; number of days alive out of hospital
- Follow-up
- 180 days
Methodological detailsprospective, 1:1 randomisation
- Prospective
- 1:1 randomisation
Primary result
All-cause mortality and HF readmissions
Hazard ratio
0.96
95% CI 0.72–1.37
P = 0.99
By group
NT-proBNP-guided vs Conventional
HR 0.96 (95% CI 0.72–1.37); P = 0.99
As reported in the abstract
Secondary outcomes
Discharged with NT-proBNP reduction >30%
P = 0.001
All-cause mortality (180 days), HF readmissions (180 days), all-cause mortality and HF readmissions (90 days)
- Guided therapy did not significantly improve any secondary end point
Original publication
NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?). Circulation. Published 14 December 2017. doi:10.
Summarised from the published abstract; every number is checked against it