Arrhythmias & electrophysiologyCohort study
Nuclear magnetic resonance-derived lipoprotein profile and risk of atrial tachyarrhythmia recurrence after catheter ablation: a case-cohort design within the PREDIMAR trial
- case-cohort study
- nested in the PREDIMAR trial
Authors' conclusion
An atherogenic lipoprotein profile characterized by elevated remnant cholesterol is associated with a higher risk of TAR after catheter ablation.
Study context
- Population
- Patients undergoing catheter ablation in the PREDIMAR (PRevención con DIeta Mediterránea de Arritmias Recurrentes) trial212 cases and 238 participants in a random sub-cohort, with 93 overlapping cases · cases 212 · random sub-cohort 238 · overlapping cases 93
- Exposure
- Baseline nuclear magnetic resonance (NMR)-derived lipoproteins (per SD) and risk of tachyarrhythmia recurrence (TAR) after catheter ablation
Main finding
TAR by baseline remnant cholesterol · 18-month follow-up
Hazard ratio
1.26 per SD
95% CI 1.06–1.51
higher baseline remnant cholesterol
hazard ratio 1.26 per SD (95% CI 1.06–1.51)
Per SD, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | hazard ratioperSD (per SD) (95% CI) |
|---|---|
| TAR by cholesterol and triglyceride content in VLDL · 18-month follow-up · increased risk of TAR | 1.22 (1.03–1.46) |
| TAR by cholesterol and triglyceride content in IDL · 18-month follow-up · increased risk of TAR | 1.29 (1.09–1.52) |
TAR by lipoprotein ratios
- Higher triglyceride-to-HDL cholesterol ratio was directly associated with recurrence
- Higher triglyceride-to-VLDL cholesterol and triglyceride-to-IDL cholesterol ratios were inversely associated with recurrence
TAR by CETP-mediated lipoprotein exchange score
- A CETP-mediated lipoprotein exchange score was directly associated with recurrence
Original publication
Nuclear magnetic resonance-derived lipoprotein profile and risk of atrial tachyarrhythmia recurrence after catheter ablation: a case-cohort design within the PREDIMAR trial. Heart Rhythm. Published 9 October 2026. doi:10.1016/j.hrthm.2026.10.002
Summarised from the published abstract; every number is checked against it