Coronary disease & ACSCohort study
Obesity and cardiovascular outcomes after myocardial infarction: a nationwide SWEDEHEART analysis by diabetes status
- Registry-based cohort study
- nationwide
- adjusted Cox proportional hazards models
- stratified by diabetes status
Authors' conclusion
In patients with myocardial infarction, obesity is common and associated with a high risk of mortality, heart failure, and renal events, especially if diabetes is present.
Study context
- Population
- Patients with myocardial infarction (MI) registered in SWEDEHEART, 2010–202121% with DM
- Participants
- 124,360 patients
- Exposure
- WHO Body mass index (BMI) strata, by diabetes status, vs normal BMI without DM
- Outcome
- Prevalence of obesity and long-term CV outcomes (mortality; MACE: all-cause death, MI, stroke or HF)
- Follow-up
- Mean 6 years
Main finding
As reported in the abstract
Mortality and MACE
Each group vs normal BMI without diabetesHR
Class 3 obesity and diabetesmortality
2.15(95% CI 1.88–2.45)
Class 3 obesity and diabetesMACE
1.91(CI 1.73–2.10)
Class 3 obesity aloneMACE
1.29(CI 1.16–1.45)
- Obesity more common with DM vs without DM
- 37% vs. 20%
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| HF and renal events — Class 3 obesity and diabetes vs Normal BMI without diabetes · HF | 2.92 (2.57–3.31) | |
| HF and renal events — Class 3 obesity and diabetes vs Normal BMI without diabetes · renal events | 3.36 (2.87–3.93) | |
| 0.20.5125Hazard ratio (log scale) |
HF and renal events
- Regardless of DM status, obesity less associated with atherosclerotic events than HF and renal events
Original publication
Obesity and cardiovascular outcomes after myocardial infarction: a nationwide SWEDEHEART analysis by diabetes status. Eur J Prev Cardiol. Published 15 July 2026. doi:10.1093/eurjpc/zwag367
Summarised from the published abstract; every number is checked against it