Heart failure & cardiomyopathiesSecondary analysis
Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial
- Secondary analysis of the REDUCE LAP-HF II randomised trial
Authors' conclusion
Increasing severity of obesity was associated with greater cardiac remodelling, higher right and left ventricular filling pressures, higher cardiac output and increased subsequent heart failure events.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) (EF ≥40%, exercise pulmonary capillary wedge pressure (PCWP) ≥25 mmHg) randomised to atrial shunt or sham procedure
- Participants
- 626 patients
- Comparison
- Severity of obesity
- Primary endpoint
- Relationship between severity of obesity and clinical, echocardiographic and haemodynamic parameters
Primary result
As reported in the abstract
Patients with body mass index (BMI) ≥30 kg/m²
60.9%
Further findings
HF events
- Obesity associated with more first and recurrent HF events
Atrial shunt treatment effect by obesity
- No significant interaction between obesity and treatment effects of the atrial shunt
Original publication
Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial. Eur J Heart Fail. Published 7 December 2023. doi:10.1002/ejhf.3092
Summarised from the published abstract; every number is checked against it