Coronary disease & ACSCohort study
Occupational exposure to diesel engine exhaust and first-time acute myocardial infarction: a nationwide register-based cohort study 1976–2018
- Register-based cohort study
- nationwide
Authors' conclusion
Increasing exposure to DEE was associated with increasing IRR for first-time AMI across different exposure measures.
Study context
- Population
- Danish working population aged 35–50 years in 1995; job history 1976–2017, follow-up 1996–201835,511 acute myocardial infarction (AMI) cases
- Participants
- 903,415 participants
- Exposure
- Cumulative occupational diesel engine exhaust (DEE) exposure by percentile category
- Outcome
- First-time AMI
- Follow-up
- 1996-2018
Main finding
As reported in the abstract
First-time AMI, cumulative DEE exposure (fully adjusted)
Incidence rate ratio (95% CI)
50th–75th percentile
1.04(1.00–1.08)
≥75th percentile
1.08(1.04–1.12)
Observational data: associations, not effects.
Further findings
First-time AMI, recent DEE exposure (highest exposed quartile)
| Comparison | IRR (95% CI) | |
|---|---|---|
| Highest exposed quartile · only when compared within exposed workers | 1.15 (1.05–1.27) | |
| 0.512Incidence rate ratio (log scale) |
Original publication
Occupational exposure to diesel engine exhaust and first-time acute myocardial infarction: a nationwide register-based cohort study 1976–2018. Eur J Prev Cardiol. Published 18 January 2025. doi:10.1093/eurjpc/zwaf022
Summarised from the published abstract; every number is checked against it