Coronary disease & ACSSecondary analysis
OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention
- Secondary analysis of the ILUMIEN IV randomised trial
- core laboratory analysis
Authors' conclusion
Based on preprocedural OCT, PCI of calcific and fibrotic plaques was associated with the highest and lowest 2-year rates of TVF and ID-TVR, respectively, with lipidic plaques being of intermediate risk.
Study context
- Population
- Patients undergoing optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) of a single de novo lesion in the ILUMIEN IV trialof 1,233 OCT-guided
- Participants
- 926 patients
- Comparison
- Predominant OCT plaque morphology: calcific vs lipidic vs fibrotic
- Lipidicn = 309
- Calcificn = 252
- Fibroticn = 365reference
- Primary endpoint
- Target-vessel failure:
- Cardiac death
- Target-vessel MI
- Ischemia-driven target-vessel revascularization
- Follow-up
- 2 years
Primary result
Target-vessel failure (TVF)
Adjusted hazard ratio
2.20
95% CI 1.12–4.33
P = 0.02
By group
Calcific vs Fibrotic
adjusted HR 2.20 (95% CI 1.12–4.33); P = 0.02
As reported in the abstract
Further findings
| Outcome | Lipidic | Calcific | Fibrotic | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| ID-TVR · 2 years | 4.0% | 8.2% | 3.1% | 2.31 (1.08–4.96) | P = 0.03 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention. JACC Cardiovasc Imaging. doi:10.1016/j.jcmg.2026.05.015
Summarised from the published abstract; every number is checked against it