Coronary disease & ACSRandomised controlled trial
Optical Coherence Tomography (OCT) vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified Lesions
- Randomised controlled trial
- prospective
- multicentre
- open-label
- 12 sites in France
- Conducted December 2021 to June 2023
Authors' conclusion
The CALIPSO randomized clinical trial showed that OCT guidance associated with predefined algorithmic management achieved better stent implantation results than angiography guidance in patients with calcified lesions PCI, without any additional safety concern.
Study context
- Population
- Patients with stable moderate to severe calcified coronary lesions scheduled for percutaneous coronary intervention (PCI)134 analysed
- Participants
- 143 patients
- Comparison
- OCT-guided PCI vs angiography-guided PCI
- OCTn = 65
- Angiographyn = 69reference
- Primary endpoint
- Minimal stent area (MSA) measured by OCT
Primary result
As reported in the abstract
Final MSA
P < 0.001
Further findings
Use of intravascular lithotripsy
P < 0.001
Safety
Periprocedural complications, contrast medium volume, procedure duration
- No difference between groups
Original publication
OCT vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified Lesions. JAMA Cardiol. Published 1 July 2025. doi:10.1001/jamacardio.2025.0741
Summarised from the published abstract; every number is checked against it