Randomised controlled trial
On-Site Computed Tomography–Derived Fractional Flow Reserve to Guide Management of Patients With Stable Coronary Artery Disease: The TARGET Randomized Trial
- Randomised controlled trial
- multicentre
Authors' conclusion
On-site CT-FFR using machine learning reduced the proportion of patients with stable coronary artery disease undergoing invasive coronary angiography without obstructive disease or requiring intervention within 90 days, but increased revascularization overall without improving symptoms or quality of life, or reducing major adverse cardiovascular events.
Study context
- Population
- Patients with stable CAD and an intermediate stenosis of 30% to 90% on coronary CT angiography, 6 Chinese centres
- Participants
- 1,216 patients
- Comparison
- On-site CT-FFR care pathway vs standard care
- CT-FFR caren = 608
- Standard caren = 608reference
- Primary endpoint
- Proportion of patients undergoing invasive coronary angiography without obstructive CAD or with obstructive disease not undergoing intervention
- Follow-up
- Within 90 days
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
Invasive coronary angiography performed
Revascularization overall
P = 0.02
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACE · 1 year | 0.88 (0.59–1.30) | ||
| 0.512Hazard ratio (log scale) |
| Outcome | difference (95% CI) | P value |
|---|---|---|
| Medical costs · trend towards lower costs | -¥4233 (-¥8165 to ¥973) | P = 0.07 |
Quality of life and symptoms
- Improved similarly in both groups
Original publication
On-Site Computed Tomography–Derived Fractional Flow Reserve to Guide Management of Patients With Stable Coronary Artery Disease: The TARGET Randomized Trial. Circulation. Published 4 March 2023. doi:10.1161/circulationaha.123.063996
Summarised from the published abstract; every number is checked against it