Valvular & structural heart diseaseCohort study
One-year follow-up of patients with severe tricuspid regurgitation: prognostic impact of right heart failure staging
- nationwide registry
- prospectively enrolled consecutive patients
- 48 centres
- 1-year follow-up
- multivariable analysis
Authors' conclusion
Massive and torrential TR identify patients at the highest risk. The modified RHFS stratifies patients with STR into prognostic categories and may help guide the timing of intervention.
Study context
- Population
- Consecutive patients with severe tricuspid regurgitation (STR) enrolled from 48 centres over 6 monthspatients included (mean age 76.7 ± 10.5 years, 70.2% women)
- Participants
- 1,247 patients
- Exposure
- prognostic impact of a modified right heart failure staging
Main finding
As reported in the abstract
HF hospitalization · During follow-up
HF hospitalization
20.8%
Observational data: associations, not effects.
Further findings
HF hospitalization, Stages III-IV of the modified right heart failure staging (RHFS)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Stages III-IV of the modified RHFS · multivariable analysis; comparator not stated · independently associated | 1.58 (1.13–2.23) | P = 0.008 | |
| 0.512Hazard ratio (log scale) |
cardiovascular mortality, Stages III-IV of the modified RHFS
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Stages III-IV of the modified RHFS · multivariable analysis; comparator not stated · independently associated | 2.01 (1.27–3.18) | P = 0.003 | |
| 0.20.5125Hazard ratio (log scale) |
cardiovascular mortality, by TR severity
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| massive TR · comparator not stated | 1.72 (1.02–2.91) | P = 0.041 | |
| torrential TR · comparator not stated | 2.57 (1.24–5.34) | P = 0.011 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Stages III-IV of the modified RHFS | severe TR | massive TR | torrential TR | Estimate | P value |
|---|---|---|---|---|---|---|
| TR severity distribution | Not reported in the abstract | 64.9% | 24.1% | 11.0% |
cardiovascular death · During follow-up
- cardiovascular death
- 9.2%
tricuspid intervention · During follow-up
- underwent tricuspid intervention
- 12.3%
Aetiology
- V-STR due to left-heart disease (most frequent)
- 49.9%
- A-STR
- 19.8%
Original publication
One-year follow-up of patients with severe tricuspid regurgitation: prognostic impact of right heart failure staging. ESC Heart Fail. Published 17 January 2026. doi:10.1093/eschf/xvag025
Summarised from the published abstract; every number is checked against it