Heart failure & cardiomyopathiesCohort study
One-year multicenter prospective real-world study of vericiguat effectiveness and safety in Spain
- prospective, multicentre registry
- consecutive patients
- 41 centres in Spain
Authors' conclusion
Vericiguat added to optimized quadruple therapy was associated with reverse remodelling, reduced NT-proBNP, improved functional class, and a numerical reduction in HF-related events in real-world HFrEF patients. These findings confirm the clinical utility and safety of vericiguat in routine practice.
Study context
- Population
- Patients with heart failure and reduced ejection fraction (HFrEF) following recent decompensation initiating vericiguat in routine clinical practice in Spainconsecutive patients initiating vericiguat
- Participants
- 835 patients
Main finding
As reported in the abstract
baseline
61.7%
12 months
63.0%
P
P = .526
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Predictor of discontinuation: higher baseline NT-proBNP (per 1000-pg/ml increase) · independently predicted discontinuation | 1.06 (1.03–1.08) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
NT-proBNP · 1-year follow-up
- baseline
- 3532.0 (IQR: 1689.3-6974.5)
- 1 year
- 2291.5 pg/ml (IQR: 1063.0-5076.3)
- P
- P < 0.001
LVEF · 1-year follow-up
- baseline
- 30.3% (SD: 7.6)
- 1 year
- 35.4% (SD: 11.1)
- P
- P < 0.001
NYHA class II patients · 1-year follow-up
- baseline
- 55.6%
- 1 year
- 62.2%
- P
- P < 0.001
Mean HF decompensations requiring intravenous diuretics
- preceding year
- 1.34 (SD: 1.1)
- during follow-up
- 0.65 (SD: 1.3)
Non-HF cardiovascular hospitalizations
- before
- 0.98 (SD: 1.4)
- during follow-up
- 0.39 (SD: 1.0)
Baseline characteristics and therapy
- age
- 71.3 years [SD: 11.2]
- male
- 78.9%
- SGLT2i
- 91.5%
- beta-blockers
- 90.7%
- RAASi
- 85.4%
- MRAs
- 79.8%
Safety
Vericiguat discontinuation
- discontinued
- 13.4%
- of discontinuations, due to symptomatic hypotension
- 49.4%
Original publication
Summarised from the published abstract; every number is checked against it