Acute cardiac care & resuscitation
Opioid-Associated vs Undifferentiated Out-of-Hospital Cardiac Arrest: Examining differences in outcomes and the relationship with Utstein variables
Main finding · Survival with favourable neurological outcomesResult — go to the resultOdds ratio 1.02 95% CI 0.77–1.35Authors' conclusion
Overall, we did not detect an association between opioid toxicity and outcomes. In models with interaction terms, the relationship between Utstein and outcomes differed between opioid-associated and other OHCAs, highlighting the impact opioid-associated cases may have in observational OHCA analyses.
Study context
- Population
- Adult Emergency Medical Services (EMS)-treated Out-of-hospital Cardiac Arrest (OHCAs) from the British Columbia Cardiac Arrest RegistryOA-OHCA 1,349 · undifferentiated 9,437
- Participants
- 10,786 OHCAs
- Exposure
- OA-OHCA
- OA-OHCAn = 1,349
- undifferentiated OHCAn = 9,437reference
Methodological detailsmultivariable logistic regression, pre-specified interaction terms
- Multivariable logistic regression
- Pre-specified interaction terms
Main finding
Survival with favourable neurological outcomes · hospital discharge
Odds ratio
1.02
95% CI 0.77–1.35
As reported in the abstract
Observational data: associations, not effects.
Further findings
Baseline characteristics
Share of OHCAs
Female, of the 1349 OA-OHCA OA-OHCA 331 (25%)
Median age OA-OHCA 40 years (IQR 31-50) · undifferentiated OHCA 70 years (IQR 58-81)
Female, of the 9437 undifferentiated undifferentiated OHCA 2910 (31%)
Interactions with Utstein variables
- Sex
- P = 0.032
- Initial cardiac rhythm
- P = 0.024
- Bystander-witnessed status
- P = <0.001
Original publication
Summarised from the published abstract; every number is checked against it