Acute cardiac care & resuscitationCohort study
Opioid-Associated vs Undifferentiated Out-of-Hospital Cardiac Arrest: Examining differences in outcomes and the relationship with Utstein variables
- Registry analysis
- multivariable logistic regression
- pre-specified interaction terms
Authors' conclusion
Overall, we did not detect an association between opioid toxicity and outcomes. In models with interaction terms, the relationship between Utstein and outcomes differed between opioid-associated and other OHCAs, highlighting the impact opioid-associated cases may have in observational OHCA analyses.
Study context
- Population
- Adult Emergency Medical Services (EMS)-treated OHCAs from the British Columbia Cardiac Arrest RegistryOA-OHCA 1,349 · undifferentiated 9,437
- Participants
- 10,786 OHCAs
- Exposure
- OA-OHCA
- OA-OHCAn = 1,349
- undifferentiated OHCAn = 9,437reference
Main finding
Survival with favourable neurological outcomes · hospital discharge
Odds ratio
1.02
95% CI 0.77–1.35
As reported in the abstract
Observational data: associations, not effects.
Further findings
Baseline characteristics
share of OHCAs
female, of the 1349 OA-OHCA OA-OHCA 331 (25%)
median age OA-OHCA 40 years (IQR 31-50) · undifferentiated OHCA 70 years (IQR 58-81)
female, of the 9437 undifferentiated undifferentiated OHCA 2910 (31%)
Interactions with Utstein variables
- sex
- P = 0.032
- initial cardiac rhythm
- P = 0.024
- bystander-witnessed status
- P = <0.001
Original publication
Summarised from the published abstract; every number is checked against it