Valvular & structural heart diseaseResearch article
Opportunistic CT Fatty Muscle Fraction for Outcome Prediction in Patients Undergoing Transcatheter Mitral Valve Edge-to-Edge Repair
- study
- single-centre (Heart Center Bonn)
- opportunistic use of routine preinterventional contrast-enhanced computed tomography
- deep learning-based segmentation algorithm
Authors' conclusion
Computed tomography-derived FMF, as a potentially new frailty marker, is independently associated with all-cause mortality in patients undergoing M-TEER and may serve as a promising parameter for risk stratification.
Study context
- Population
- Patients undergoing M-TEER between 2010 and 2022 at the Heart Center Bonn who received preprocedural contrast-enhanced computed tomographypatients investigated
- Participants
- 197 patients
- Comparison
- Tertiles of fatty muscle fraction (FMF) measured at the L3 vertebral level on CT
- Outcome
- All-cause mortality
- Follow-up
- 1 year following the procedure
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
FMFmultivariable Cox regression; independent predictor
1.05(1.02–1.08)
P < 0.001agemultivariable Cox regression
0.96(0.93–1.00)
P = 0.023male gendermultivariable Cox regression
3.65(1.67–7.975)
P < 0.001Further findings
All-cause mortality · 30 days
All-cause mortality · 2 years
All-cause mortality · 3 years
- FMF in 1-year survivors vs nonsurvivors: One-year survivors median 49.0% (IQR 39.0–58.7)
- FMF in 1-year survivors vs nonsurvivors: nonsurvivors median 57.6% (IQR 49.6–69.2)
- FMF in 1-year survivors vs nonsurvivors: P <0.001
- All-cause mortality: P =0.005
- All-cause mortality: P =0.005
- All-cause mortality: P =0.005
Original publication
Opportunistic CT Fatty Muscle Fraction for Outcome Prediction in Patients Undergoing Transcatheter Mitral Valve Edge-to-Edge Repair. Circ Cardiovasc Imaging. Published 7 May 2026. doi:10.1161/circimaging.125.018763
Summarised from the published abstract; every number is checked against it