Heart failure & cardiomyopathiesCohort study
Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction
- Retrospective registry study
- multicentre
- GWTG-HF Registry 2017-2020
Authors' conclusion
Nearly 1 in 6 patients received all indicated HF-related medications on admission, increasing to 1 in 3 on discharge with an average of 1 new medication initiation.
Study context
- Population
- Hospitalised patients with heart failure with reduced ejection fraction (HFrEF) in the GWTG-HF Registry, 2017–2020
- Participants
- 50,170 patients · 160 sites
- Outcome
- Opportunities for and achievement of HF medication initiation (7 evidence-based HF-related medications: eligible, used before admission, prescribed at discharge)
- Follow-up
- Hospitalisation (admission to discharge)
Main finding
As reported in the abstract
Evidence-based HF medications per patient
- Eligible medications, mean
- 3.9 ± 1.1
- Used before admission, mean
- 2.1 ± 1.3
- Prescribed on discharge, mean
- 3.0 ± 1.0
- Receiving all indicated medications at admission
- 14.9%
- Receiving all indicated medications at discharge
- 32.8%
- Mean net gain in medications
- 0.9 ± 1.3
- Mean length of stay (days)
- 5.6 ± 5.3
Observational data: associations, not effects.
Further findings
Odds of medication initiation over time · 2017-2020
| Comparison | adjusted OR (95% CI) | |
|---|---|---|
| study period · increased during the study period | 1.08 (1.06–1.10) | |
| 0.512Adjusted odds ratio (log scale) |
Factors associated with heart failure (HF) medication initiation (multivariable analysis)
- Lower odds of initiation with older age, female sex, pre-existing conditions (stroke, peripheral arterial disease, pulmonary disease, renal insufficiency) and rural location
Original publication
Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction. JACC Heart Fail. Published 14 June 2023. doi:10.1016/j.jchf.2023.04.015
Summarised from the published abstract; every number is checked against it