Coronary disease & ACSRandomised controlled trial
Optical Coherence Tomography–Guided or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial
- Randomised controlled trial
- prospective
- multicentre
- open-label
- pragmatic
- non-inferiority
Authors' conclusion
In patients with significant coronary artery lesions, OCT-guided PCI was noninferior to IVUS-guided PCI with respect to the incidence of a composite of death from cardiac causes, target vessel-related myocardial infarction, or ischemia-driven target-vessel revascularization at 1 year.
Study context
- Population
- Patients with significant coronary artery lesions undergoing percutaneous coronary intervention (PCI)
- Participants
- 2,008 patients
- Comparison
- Optical coherence tomography (OCT)-guided vs intravascular ultrasound (IVUS)-guided PCI
- OCTn = 1,005
- IVUSn = 1,003reference
- Primary endpoint
- Composite of:
- Cardiac death
- Target vessel-related MI
- Ischemia-driven target-vessel revascularization
- Follow-up
- 1 year
Primary result
As reported in the abstract
Absolute difference
−0.6 percentage points
one-sided 97.5% CI upper boundary 0.97
P < 0.001 for non-inferiority
Events by treatment group
Safety
Contrast-induced nephropathy · similar
P = 0.85
Major procedural complications · lower with OCT
P = 0.047
Major procedural complications
- Imaging procedure-related complications not observed
Original publication
Optical Coherence Tomography–Guided or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial. Circulation. Published 27 August 2023. doi:10.1161/circulationaha.123.066429
Summarised from the published abstract; every number is checked against it