Heart failure & cardiomyopathiesCohort study
Optimal left ventricular ejection fraction in risk stratification of patients with cardiac sarcoidosis
- Retrospective cohort study
Authors' conclusion
Among patients with CS, a mild reduction in LVEF of 42% was identified as the optimal cutoff for predicting VA and all-cause mortality. Prior VA and scar by CMR or PET are strong risk factors for future VA and all-cause mortality.
Study context
- Population
- Patients with well-established cardiac sarcoidosis
- Participants
- 273 patients
- Outcome
- Composite of:
- Ventricular arrhythmia
- All-cause mortality
Main finding
As reported in the abstract
Primary composite endpoint:
- VA
- All-cause mortality
Rate of primary endpoint (83 ventricular arrhythmia (VAs) and 32 all-cause deaths)
38%
Optimal left ventricular ejection fraction (LVEF) cutoff for primary endpoint, entire cohort and subjects without history of VA
42%
Observational data: associations, not effects.
Further findings
Overall survival · 5 years
- 5-year overall survival rate
- 97%
All-cause mortality risk factors
- Independent risk factors: lower LVEF, baseline NT-proBNP, any presence of scar
Original publication
Optimal left ventricular ejection fraction in risk stratification of patients with cardiac sarcoidosis. Europace. Published 18 September 2023. doi:10.1093/europace/euad273
Summarised from the published abstract; every number is checked against it