Coronary disease & ACSRandomised controlled trial
Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial
- Randomised controlled trial
Authors' conclusion
The randomized CENTURY trial demonstrates that comprehensive integrated lifestyle modification and medical management towards goals with revascularization reserved for severely reduced CFC, significantly reduced risk factor scores, death, death or MI, and revascularization.
Study context
- Population
- Chronic stable coronary artery disease (CAD), 2009–2017followed ≥5 years
- Participants
- 1,028 participants
- Comparison
- Comprehensive care vs standard care
- Comprehensive caren = 515
- Standard caren = 513reference
Primary result
As reported in the abstract
Comprehensive care
−1.1
Δ
Standard care
+ 0.33
Δ
95% CI −1.84 to −0.97; P < 0.0001
Further findings
All-cause death · 11 years, cumulative
P = 0.023
Death or MI · 11 years, cumulative
P = 0.024
Late revascularization · 11 years, cumulative
P = 0.021
Major adverse cardiac events · 11 years, cumulative
P = 0.0006
Revascularization within 90 days (all patients)
- Revascularization within 90 days, predominantly guided by coronary flow capacity (CFC) severity
- 56 of 1028 (5.4%)
Original publication
Summarised from the published abstract; every number is checked against it