Heart failure & cardiomyopathies
Optimal Medical Therapy and Outcomes Among Patients With Chronic Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Across a large cohort of chronic ambulatory HFrEF, OMT scores stratified risk of all-cause and cardiovascular death.
Study context
- Population
- US outpatients with chronic heart failure with reduced ejection fraction (HFrEF) receiving ≥1 guideline-directed medical therapy (GDMT) (CHAMP-HF)available 2-year follow-up
- Participants
- 4,582 outpatients
- Exposure
- Optimal vs acceptable vs suboptimal medical therapy
- Suboptimaln = 1,628reference
- Acceptablen = 665
- Optimaln = 2,289
- Outcome
- All-cause and CV death
- Follow-up
- 2-year follow-up
Methodological detailsmulticentre, adjusted Cox proportional hazards analysis
- Multicentre
- Adjusted Cox proportional hazards analysis
Main finding
As reported in the abstract
Optimal vs SuboptimalAdjusted hazard ratio (95% CI)
All-cause death
0.77(0.64–0.92)
CV death
0.79(0.65–0.96)
Observational data: associations, not effects.
Further findings
Median optimal medical therapy (OMT) score
- Median OMT score across the population (Q1-Q3: 2-5)
- 4
Characteristics of Optimal vs Acceptable or Suboptimal
- Optimal: younger, higher annual household income, enrolled from practices with dedicated HF clinics
- all P < 0.001
Original publication
Optimal Medical Therapy and Outcomes Among Patients With Chronic Heart Failure With Reduced Ejection Fraction. JACC Heart Fail. Published 7 August 2024. doi:10.
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