Cardiometabolic & kidneyCohort study
Optimizing Care in Cardiovascular-Kidney-Metabolic Syndrome: Registry Data From the Cardiometabolic Center Alliance
- prospective clinical cohort study
- 9 US sites
- longitudinal mixed-effects models accounting for clustering by site
- Consecutive patients
Authors' conclusion
The Cardiometabolic Center Alliance model is feasible and effective, leading to significant improvement in CVD risk factors and increased utilization of GDMT. Implementation and dissemination of this paradigm remains a priority to close gaps in cardiometabolic care.
Study context
- Population
- Patients with type 2 diabetes/prediabetes and cardiovascular diseases (CVD) and chronic kidney disease enrolled in a team-based clinical program of the Cardiometabolic Center Alliance, May 2020 to August 2024individuals enrolled
- Participants
- Two thousand two hundred twenty-three patients
Main finding
As reported in the abstract
Change in cardiometabolic risk factors · Median follow-up 6.8 (4.0-9.4) months
- Weight, mean [95% CI]
- −16.7 [−17.9 to −15.6] lbs
- Body mass index
- −2.6 [−2.8 to −2.4] kg/m 2
- Systolic blood pressure
- −5.8 [−7.0 to −4.6] mm Hg
- Diastolic blood pressure
- −1.7 [−2.4 to-0.9] mm Hg
- Total cholesterol
- −26.4 [−29.5 to −23.2] mg/dL
- Low-density lipoprotein cholesterol
- −18.8 [−21.4 to −16.2] mg/dL
- Triglycerides
- −45.1 [−54.0 to −36.3] mg/dL
- Fasting glucose
- −30.9 [−35.4 to −26.4] mg/dL
- HbA1c
- −1.2 [−1.3% to −1.0%]
- Insulin dose
- −30.4 [−36.1 to −24.8] units/d
Observational data: associations, not effects.
Further findings
Guideline-directed medical therapy
- Atherosclerotic CVD type 2 diabetes: increased from 31.0% to
- 59.6%
- Chronic kidney disease type 2 diabetes: increased from 33.3% to
- 63.8%
- P <0.001
Baseline characteristics
- Mean (SD) age
- 63.9 (11.2) years
- Female
- 44.2%
- White
- 84.0%
- Noncommercially insured
- 62.5%
- Atherosclerotic CVD
- 58.5%
- Heart failure
- 32.6%
- Chronic kidney disease
- 29.5%
Original publication
Optimizing Care in Cardiovascular-Kidney-Metabolic Syndrome: Registry Data From the Cardiometabolic Center Alliance. Circ Popul Health Outcomes. Published 22 June 2026. doi:10.1161/circoutcomes.125.012828
Summarised from the published abstract; every number is checked against it