Heart failure & cardiomyopathiesCohort study
Optimizing Triage of Ambulatory Patients With Advanced Heart Failure
- Prospective observational registry study
- multicentre (21 left ventricular assist device (LVAD) centers)
Authors' conclusion
REVIVAL patients not selected for VAD or transplant have robust survival and patient-reported outcomes, which challenges advocacy for earlier VAD implantation.
Study context
- Population
- Ambulatory patients with advanced systolic heart failure (HF) on guideline-directed medical therapy (GDMT), ≥1 HF mortality risk marker, no LVAD contraindication
- Participants
- 400 patients · 21 LVAD centers
- Outcome
- Death, durable ventricular assist device, or urgent transplant
- Follow-up
- 2 years
Main finding
As reported in the abstract
Composite primary outcome · 1 and 2 years
Composite primary outcome at 1 year
22%
Composite primary outcome at 2 years
37%
Observational data: associations, not effects.
Further findings
Death alone · 1 and 2 years
- Death at 1 year
- 8%
- Death at 2 years
- 16%
GDMT intensity and health-related quality of life in 2-year survivors
- Maintained GDMT intensity and no decline in health-related quality of life
Original publication
Optimizing Triage of Ambulatory Patients With Advanced Heart Failure. JACC Heart Fail. Published 3 July 2024. doi:10.1016/j.jchf.2024.05.008
Summarised from the published abstract; every number is checked against it