HypertensionMeta-analysis
Orthostatic hypertension and major adverse events: a systematic review and meta-analysis
- Systematic review and meta-analysis
- random-effects
- Quality (Newcastle-Ottawa): 11 good, 8 fair, 1 poor
Median (IQR) follow-up of prospective studies 7.85 (4.12, 10.83) years
Authors' conclusion
Patients with SOHT may have higher mortality risk relative to those with ONT and increased odds of stroke/cerebrovascular disease.
Study context
- Population
- Adults aged ≥18 years in observational/interventional studies assessing orthostatic hypertension
- Participants
- 61,669 adults · 20 studies
- Comparison
- Systolic orthostatic hypertension (OHT) vs orthostatic normotension
- Outcome
- All-cause mortality
Pooled result
As reported in the abstract
Hazard ratio
1.21
95% CI 1.05–1.40
SOHT vs ONT
HR 1.21 (95% CI 1.05–1.40)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| CV mortality · two studies | HR 1.39 (95% CI 1.05–1.84) | |
| Stroke/cerebrovascular disease | OR 1.94 (95% CI 1.52–2.48) | |
| 0.512Ratio (log scale) |
Other outcomes (CHD, HF, neurocognitive decline)
- No association; possibly weak evidence or low statistical power
Original publication
Orthostatic hypertension and major adverse events: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 18 May 2023. doi:10.1093/eurjpc/zwad158
Summarised from the published abstract; every number is checked against it