Valvular & structural heart diseaseSecondary analysis
Osteosarcopenia and Mortality in Older Adults Undergoing Transcatheter Aortic Valve Replacement
- Post hoc analysis of the FRAILTY-AVR prospective cohort study
- multicentre
- 14 centres in Canada, US and France
- McGill extension
Authors' conclusion
The findings suggest that osteosarcopenia detected using clinical CT scans could be used to identify frail patients with a 3-fold increase in 1-year mortality following TAVR.
Study context
- Population
- Patients aged ≥70 years undergoing transcatheter aortic valve replacement (TAVR), 2012–2022271 [45%] female
- Participants
- 605 patients
- Comparison
- Osteosarcopenia vs Normal bone and muscle status
- Osteosarcopenian = 91
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Primary result
1-year mortality
Odds ratio
3.18
95% CI 1.54–6.57
Events by treatment group
Osteosarcopenia vs Normal bone and muscle status
OR 3.18 (95% CI 1.54–6.57)
As reported in the abstract
- Difference in 1-year mortality across the four groups
- P < 0.001
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| 1-year worsening disability · multivariable-adjusted | 2.11 (1.19–3.74) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Osteosarcopenia and Mortality in Older Adults Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiol. Published 1 July 2024. doi:10.1001/jamacardio.2024.0911
Summarised from the published abstract; every number is checked against it