Heart failure & cardiomyopathiesCohort study
Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation
- Retrospective cohort study
- international
- multicentre
- 22 heart transplant centres
Authors' conclusion
In an international study of DCD HT, recipients of hearts retrieved by taNRP technique had lower rates of severe PGD and fewer episodes of biopsy-proven ACR in the first year when compared with those retrieved by using DPP.
Study context
- Population
- Patients undergoing DCD heart transplantation in Belgium, Spain, UK and US, from start of each centre's DCD program through January 1, 2023
- Participants
- 504 DCD heart transplantation (HTs)
- Exposure
- Thoraco-abdominal normothermic regional perfusion (taNRP) vs direct procurement and perfusion (DPP) for DCD heart procurement
- Outcome
- Survival; severe primary graft dysfunction (PGD); treated, biopsy-proven acute-cellular rejection (ACR)
- Follow-up
- 1 year
Main finding
As reported in the abstract
1-year survival
P = 0.100
Severe PGD
P < 0.001
Treated biopsy-proven ACR, first year
P < 0.001
Observational data: associations, not effects.
Original publication
Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation. JACC Heart Fail. Published 27 April 2025. doi:10.1016/j.jchf.2025.04.003
Summarised from the published abstract; every number is checked against it