Heart failure & cardiomyopathiesResearch article
Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy
- Outcomes after repeat alcohol septal ablation (ASA) in patients with obstructive hypertrophic cardiomyopathy
Authors' conclusion
The site of residual obstruction may be important for understanding long-term outcomes after repeat ASA, but this requires further studies.
Study context
- Population
- Patients with obstructive hypertrophic cardiomyopathy who underwent repeat alcohol septal ablation (ASA)repeat ASA, of 663 patients who underwent ASA · proximal obstruction 41 · distal obstruction 43
- Participants
- 84 patients
- Comparison
- Proximal vs distal residual left ventricular (LV) obstruction
- proximal obstructionn = 41
- distal obstructionn = 43reference
- Outcome
- Absence of symptomatic residual LV obstruction (NYHA functional class I or LV gradient <50 mm Hg, or both)
- Follow-up
- 12 months after repeat ASA
Main finding
As reported in the abstract
Adjusted odds ratio
4.06
95% CI 1.09–18.3
Events by group
proximal obstruction vs distal obstruction
adjusted OR 4.06 (95% CI 1.09–18.3)
- Overall achieved primary endpoint
- 80.7% (67/83)
Secondary outcomes
Deaths · median follow-up of 7.1 years
- deaths
- 13 deaths (15.5%)
Cardiovascular mortality and heart failure hospitalization
- Similar between proximal and distal obstruction
Fatal arrhythmia and 3rd interventions
- More frequent in distal obstruction
Technical success
- Patients failing to achieve technical success
- Five
Safety
| Outcome | proximal obstruction | distal obstruction |
|---|---|---|
| Death due to infection during the index hospitalization | One events | Not reported in the abstract |
Original publication
Outcomes After Repeat Alcohol Septal Ablation in Patients With Obstructive Hypertrophic Cardiomyopathy. JACC Adv. Published 14 February 2026. doi:10.1016/j.jacadv.2026.102595
Summarised from the published abstract; every number is checked against it