Heart failure & cardiomyopathiesCohort study
Outcomes at One Year in Women with Peripartum Cardiomyopathy: Findings from the ESC EORP PPCM Registry
- Prospective registry study
- multinational
- 51 countries
Authors' conclusion
Approximately 1 in 12 women with PPCM had died by 1 year and thromboembolism and stroke occurred in 6.3% and 2.5%, respectively. Around 1 in 7 women had been rehospitalized and, in 1 in 3, LV recovery had not occurred. PPCM is associated with substantial mortality and morbidity globally.
Study context
- Population
- Women with PPCM (peripartum state, HF signs or symptoms, LVEF ≤45%, alternative causes of HF excluded), ESC EORP PPCM Registry, 2012–2018535 (71%) with 1-year mortality data
- Exposure
- Regions
Main finding
As reported in the abstract
All-cause death · 1 year
- Overall all-cause death at 1 year
- 8.4%
- Regional variation
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Europe | Africa | Asia-Pacific | Middle East |
|---|---|---|---|---|
| LV recovery · 1 year · Asia-Pacific most frequent, Middle East least frequent | Not reported in the abstract | Not reported in the abstract | 77.5% | 32.7% |
- Left ventricular (LV) recovery — Overall LV recovery
- 66.1%
- LV recovery — Recovery between 6 months and 1 year
- 22%
- LV recovery — Mean LVEF increase from baseline
- 21.2% (±13.6)
Thromboembolism and stroke · 1 year
- Thromboembolism
- 6.3%
- Stroke
- 2.5%
- Similar across regions
Rehospitalization · 1 year
- At least one rehospitalization
- 14.0%
- Recurrent rehospitalizations (two or more)
- 3.5%
Use of HF pharmacotherapies
- Significant regional differences
Original publication
Outcomes at One Year in Women with Peripartum Cardiomyopathy: Findings from the ESC EORP PPCM Registry. Eur J Heart Fail. Published 31 October 2023. doi:10.1002/ejhf.3055
Summarised from the published abstract; every number is checked against it