Valvular & structural heart diseaseCohort study
Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification
- Registry-based cohort study
- multicentre
- consecutive patients
Authors' conclusion
TMVR in patients with MACmod/sev is associated with higher rates of postprocedural complications but similar rates of survival, MR resolution, and functional improvement compared to MACnone/mild.
Study context
- Population
- Patients with symptomatic mitral regurgitation (MR) receiving transcatheter mitral valve replacement (TMVR) with available CT data (CHOICE-MI registry)
- Participants
- 279 patients
- Exposure
- TMVR with dedicated devices in MACmod/sev vs MACnone/mild
- MACmod/sevn = 57
- MACnone/mildn = 222reference
Main finding
As reported in the abstract
All-cause mortality · 2 years
P = 0.76
Observational data: associations, not effects.
Further findings
CV mortality · 2 years
P = 0.97
All-cause mortality or HF hospitalization · 2 years
P = 0.28
Technical success, MR elimination, functional improvement at 1 and 2 years
- Did not differ between groups
Safety
Postprocedural bleeding complications and renal failure
- Higher postprocedural bleeding complications with MACmod/sev
- P = 0.02
- Higher renal failure with MACmod/sev
- P < 0.001
Original publication
Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification. JACC Cardiovasc Interv. Published 4 September 2024. doi:10.1016/j.jcin.2024.07.038
Summarised from the published abstract; every number is checked against it