Outcomes in infants with restrictive atrial septum and pre-stage 1 palliation septal intervention
Main finding · Operative survival, post-S1P length of stay (LOS), and one-year mortalityAdjusted odds ratio 2.2 CI 1.44,3.38- Multicenter retrospective cohort study
- adjusted for demographic and clinical factors through multivariable regression
+1 more
- adjusted for demographic and clinical factors through multivariable regression
Authors' conclusion
RAS identifies a high-risk phenotype with early instability and excess early and one-year mortality. These findings highlight the need for improved risk stratification and more effective, standardized atrial decompression strategies for infants with clinically significant atrial restriction.
Study context
- Population
- Infants undergoing stage 1 palliation (S1P) from 2016 to 2024 and included in the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC)infants who underwent S1P at 70 centers
- Participants
- 3,644 infants
- Exposure
- RAS with pre-S1P intervention vs no RAS
- RAS with pre-S1P interventionn = 164
- RAS without pre-S1P interventionn = 369
- no RASn = 3,111reference
- Outcome
- Operative survival, post-S1P length of stay (LOS), and one-year mortality
Main finding
As reported in the abstract
Operative survival, post-S1P length of stay (LOS), and one-year mortality
Adjusted odds ratio
2.2
CI 1.44,3.38
P < 0.001
RAS with pre-S1P intervention vs no RAS
aOR 2.2 (CI 1.44,3.38); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | RAS with pre-S1P intervention | RAS without pre-S1P intervention | no RAS | |
|---|---|---|---|---|
| Pre-operative instability | ||||
| inotrope use | 43% | Not reported in the abstract | 15% | RAS without pre-S1P intervention: not reported in the abstract |
| mechanical ventilation | 57% | Not reported in the abstract | 19% | RAS without pre-S1P intervention: not reported in the abstract |
| persistent shock | 18% | Not reported in the abstract | 7% | RAS without pre-S1P intervention: not reported in the abstract |
| Hybrid S1P | 23% | Not reported in the abstract | 10% | RAS without pre-S1P intervention: not reported in the abstract |
- Pre-operative instability: all p<0.001
- Hybrid S1P: p<0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Outcomes in infants with restrictive atrial septum and pre-stage 1 palliation septal intervention. Am Heart J. Published 1 October 2026. doi:10.1016/j.ahj.2026.107620
Summarised from the published abstract; every number is checked against it