Heart failure & cardiomyopathies
Outcomes of cardiac resynchronization therapy in adults with congenital heart disease and heart failure with reduced ejection fraction
Main finding · MortalityAdjusted hazard ratio 0.76 95% CI 0.51–0.97- retrospective study
Authors' conclusion
These data highlight the clinical benefits of CRT and GDMT for the management of HFrEF in CHD and support the use of these therapies in this population.
Study context
- Population
- Adults with congenital heart disease (CHD), biventricular circulation, systemic left ventricle, and heart failure with reduced ejection fraction (HFrEF) at Mayo Clinic (2003–2023)patients with CHD and HFrEF, 105 (32%) received cardiac resynchronization therapy (CRT)
- Participants
- 327 adults
- Exposure
- relationship between CRT and clinical outcomes
- CRTn = 105
- CRT respondersn = 71
Main finding
Mortality
Adjusted hazard ratio
0.76
95% CI 0.51–0.97
CRT
adjusted HR 0.76 (95% CI 0.51–0.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cardiovascular events
| Comparison | adjusted HR (95% CI) | |
|---|---|---|
| CRT · 21% decrease in cardiovascular events | 0.79 (0.63–0.94) | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | adjusted odds ratio (95% CI) | |
|---|---|---|
| Odds of CRT response per higher GDMT score · greater odds of CRT response | 1.28 (1.04–1.47) | |
| 0.512Adjusted odds ratio (log scale) |
Temporal improvement in clinical indices and cardiovascular events in CRT responders
| Comparison | unadjusted HR (95% CI) | |
|---|---|---|
| CRT responders · lower risk of cardiovascular events | 0.73 (0.47–0.99) | |
| 0.512Unadjusted hazard ratio (log scale) |
CRT response
- Of the 105 patients, CRT responders
- 71 (68%)
Temporal improvement in clinical indices and cardiovascular events in CRT responders
- Greater temporal improvement in NYHA functional class, peak oxygen consumption, N-terminal pro-B-type natriuretic peptide level
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Outcomes of cardiac resynchronization therapy in adults with congenital heart disease and heart failure with reduced ejection fraction. Heart Rhythm. Published 17 April 2026. doi:10.1016/j.hrthm.2026.03.1967
Summarised from the published abstract; every number is checked against it