Valvular & structural heart disease
Outcomes of Early vs Delayed Aortic Valve Replacement: Analysis of the EARLY Transcatheter Aortic Valve Replacement (TAVR) Valve Implant Population
Primary result · Death, stroke or HF hospitalizationResult — go to the resultAdjusted hazard ratio 0.61 95% CI 0.38–0.99Authors' conclusion
Among patients with asymptomatic, severe AS, delayed AVR with AVS is associated with higher rates of death, stroke, or heart failure hospitalization compared with early TAVR
Study context
- Population
- Patients with asymptomatic, severe aortic stenosis (AS) undergoing valve implant, 75 sites75 sites
- Participants
- 444 vs 388
- Comparison
- Early TAVR vs delayed aortic valve replacement (AVR) after clinical surveillance
- Early TAVRn = 444reference
- Delayed AVRn = 388
- Primary endpoint
- Composite of:
- Death
- Stroke
- HF hospitalization
- Follow-up
- 2 years postprocedure
Methodological detailsmulticentre, valve implant population, 97.6% of early TAVR patients (444 of 455) underwent the index procedure; 87.0% of clinical surveillance (CS) patients (388 of 446) underwent delayed AVR through 5 years
- Multicentre
- Valve implant population
- 97.6% of early TAVR patients (444 of 455) underwent the index procedure; 87.0% of CS patients (388 of 446) underwent delayed AVR through 5 years
Primary result
Death, stroke or HF hospitalization
Adjusted hazard ratio
0.61
95% CI 0.38–0.99
P = 0.045
Early TAVR vs Delayed AVR
adjusted HR 0.61 (95% CI 0.38–0.99); P = 0.045
As reported in the abstract
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Primary composite by presentation: delayed AVR with acute valve syndrome (AVS) vs early TAVR — Delayed AVR with AVS vs Early TAVR | 2.12 (1.19–3.78) | P = 0.01 | |
| Primary composite by presentation: delayed AVR with acute valve syndrome (AVS) vs early TAVR — Delayed AVR with AVS vs Early TAVR · stroke | 2.92 (1.26–6.76) | P = 0.01 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
- Primary composite by presentation: delayed AVR with acute valve syndrome (AVS) vs early TAVR: 39.2% of delayed AVR presented with AVS, 58.5% with progressive valve syndrome
- Primary composite by presentation: delayed AVR with acute valve syndrome (AVS) vs early TAVR: median time to delayed AVR 11.1 months
Original publication
Outcomes of Early vs Delayed Aortic Valve Replacement: Analysis of the EARLY TAVR Valve Implant Population. JACC Cardiovasc Interv. Published 24 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it