Congenital heart diseaseCohort study
Outcomes of implantable cardioverter-defibrillator implantation in adults with congenitally corrected transposition of great arteries
- Retrospective cohort study
- Mayo Clinic (2003-2024)
Authors' conclusion
We observed a high rate of appropriate ICD shock, especially in the secondary prevention group. However, risk stratification of ICD implantation for primary prevention remains challenging. The absence of SCD (despite a high prevalence of all-cause mortality) suggest that ICD implantation may provide a survival benefit.
Study context
- Population
- Adults with congenitally corrected transposition of great arteries (cc-TGA) who underwent implantable cardioverter-defibrillator (ICD) implantationOf 278 patients, 87 (31%) underwent ICD implantation · primary prevention 67 · secondary prevention 20
- Participants
- 87 adults
- Exposure
- primary versus secondary prevention
- primary preventionn = 67
- secondary preventionn = 20
Main finding
As reported in the abstract
Appropriate ICD shock
P = 0.006
- Patients receiving appropriate ICD shock, overall
- 14 (16%)
- Annual incidence of appropriate ICD shock, overall
- 3.7% per year
Observational data: associations, not effects.
Further findings
Inappropriate ICD shock
- Patients receiving inappropriate ICD shock, overall
- 11 (13%)
- Annual incidence, overall
- 3.5% per year
- Similar between the 2 groups
Risk factors for appropriate ICD shock
- Apart from ICD implantation for secondary prevention, none of the conventional risk factors were associated with an appropriate ICD shock
All-cause mortality and sudden cardiac death (SCD)
- All-cause mortality
- 31%
- None of the patients experienced SCD
- exploratory outcome
Original publication
Outcomes of implantable cardioverter-defibrillator implantation in adults with congenitally corrected transposition of great arteries. Am Heart J. Published 21 March 2026. doi:10.1016/j.ahj.2026.107431
Summarised from the published abstract; every number is checked against it