Valvular & structural heart diseaseCohort study
Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair
- multicentre registry
Authors' conclusion
A reduction in the mLAP during M-TEER is independently associated with improved clinical outcomes in patients with DMR but not in those with FMR. These findings underscore the importance of real-time haemodynamic assessment - especially in DMR - as a valuable procedural endpoint that may aid in optimising long-term outcomes beyond anatomical MR reduction alone.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) with intraprocedural direct mean left atrial pressure (mLAP) measurements, OCEAN-Mitral registrypatients undergoing M-TEER with intraprocedural direct mLAP measurements · DMR 825 · FMR 1,804
- Participants
- 2,629 patients
- Exposure
- mLAP reduction during M-TEER, by MR aetiology
- mLAP reductionn = 1,548
- Outcome
- Composite of:
- All-cause mortality
- Heart failure (HF) rehospitalisation
Main finding
As reported in the abstract
mLAP reductionAdjusted hazard ratio (95% CI)P value
DMR cohort
0.66(0.45–0.96)
P = 0.028FMR cohort
0.90(0.75–1.08)
P = 0.251Observational data: associations, not effects.
Further findings
Pulmonary vein flow patterns
- Pulmonary vein flow patterns improved, with systolic waves becoming greater than diastolic waves across both groups; combination with the mLAP reduction predicted better outcomes only in DMR patients
Original publication
Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair. EuroIntervention. Published 15 June 2026. doi:10.4244/eij-d-26-00084
Summarised from the published abstract; every number is checked against it