Coronary disease & ACSMeta-analysis
Outcomes of Lesions With Discordance Between Fractional Flow Reserve (FFR) and Nonhyperemic Pressure Ratios
- Systematic review and meta-analysis
Authors' conclusion
Deferral of PCI in discordant-physiology was associated with worse long-term outcomes compared with the concordant-negative physiology.
Study context
- Population
- Intermediate lesions deferred for PCI after FFR and nonhyperemic pressure ratio assessment
- Participants
- 9,854 lesions · 6 trials
- Comparison
- Deferral of PCI for discordant physiology vs deferral for concordant-negative physiology
- Outcome
- Composite of:
- Death (all-cause or cardiac)
- MI/revascularization (several definitions)
- Follow-up
- Long-term
Pooled result
As reported in the abstract
Each group vs FFR-/NHPRs-Hazard ratio (CI)P value
FFR-/NHPRs+
2.73(1.95–3.80)
P < 0.00001FFR+/NHPRs-
3.29(2.33–4.64)
P < 0.00001Further pooled results
Death or MI
- Deferral in both discordant groups associated with an increase vs concordant-negative physiology
Primary endpoint, revascularization vs deferral within discordant physiology (exploratory)
- Reduction with revascularization in FFR+/nonhyperemic pressure ratios (NHPRs)-, not in FFR-/NHPRs+
- exploratory analysis
Original publication
Outcomes of Lesions With Discordance Between FFR and Nonhyperemic Pressure Ratios. JACC Cardiovasc Interv. Published 14 July 2025. doi:10.1016/j.jcin.2025.05.032
Summarised from the published abstract; every number is checked against it