Coronary disease & ACSCohort study
Outcomes of Patients With Myeloproliferative Neoplasms Admitted With Myocardial Infarction
- Retrospective cohort study
- propensity score weighting
- National Inpatient Sample
Authors' conclusion
Among patients hospitalized with AMI, patients with MPNs have a lower risk of in-hospital death or CA compared with patients without MPNs, although they have a higher risk of bleeding.
Study context
- Population
- Patients with a primary admission of acute myocardial infarction (AMI), National Inpatient Sample, January 2006 to December 2018
- Participants
- 1,644,304 unweighted admissions
- Exposure
- MPN vs no MPN
- MPNn = 5,374
- Outcome
- In-hospital death or cardiac arrest (CA); major bleeding
- Follow-up
- In-hospital
Main finding
In-hospital death or CA
Odds ratio
0.83
95% CI 0.82–0.84
MPN vs Non-MPN
OR 0.83 (95% CI 0.82–0.84)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Temporal trends, Non-MPN · 2006–2018
- Decreasing rate of in-hospital death or cardiac arrest (CA) and bleeding
- P for trend < 0.001
Temporal trends, MPN · 2006–2018
- Increasing rate of in-hospital death or CA
- P for trend < 0.001
- Stable rate of major bleeding
- P for trend = 0.48
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Major bleeding · after propensity score weighting | 1.29 (1.28–1.30) | |
| 0.512Odds ratio (log scale) |
Original publication
Outcomes of Patients With Myeloproliferative Neoplasms Admitted With Myocardial Infarction. JACC CardioOncol. Published 6 June 2023. doi:10.1016/j.jaccao.2023.03.014
Summarised from the published abstract; every number is checked against it