Valvular & structural heart diseaseCohort study
Outcomes of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Replacement (TAVR): TVT Registry Insights
- registry
- real-world
- Cox proportional hazards models adjusted for baseline demographic, clinical, and echocardiographic variables
Authors' conclusion
New LBBB after TAVR is associated with worse 1-year outcomes, including death, rehospitalization, and permanent pacemaker, as well as worse health status and lower left ventricular ejection fraction. These findings suggest that continued efforts to limit the development of conduction disturbance after TAVR are warranted.
Study context
- Population
- Patients in the TVT registry who underwent TAVR for aortic stenosis between 2016 and 2022 and were discharged alive from the index hospitalization, excluding preexisting conduction defects and a permanent pacemaker before TAVR or during the index hospitalization
- Participants
- 202,533 TAVR recipients
- Exposure
- Clinical outcomes were compared between patients with and without new left bundle branch block (LBBB)
- new LBBBn = 32,933
Main finding
As reported in the abstract
Incidence of new LBBB over the study period · first quarter of 2016 to third quarter of 2022
first quarter of 2016
19.9%
third quarter of 2022
14.4%
Observational data: associations, not effects.
Further findings
| Outcome | adjusted hazard ratio (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · 1-year | 1.19 (1.13–1.25) | P < 0.001 | |
| Hospital readmission · 1-year | 1.23 (1.19–1.28) | P < 0.001 | |
| New pacemaker requirement · 1-year | 3.50 (3.26–3.76) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | adjusted difference (points) (95% CI) | P value | |
|---|---|---|---|
| Kansas City Cardiomyopathy Questionnaire Overall Summary scores · lower with new LBBB | −1.7 (−2.1 to −1.3) | P < 0.001 | |
| −3−2−101Difference, points (linear scale) |
| Outcome | adjusted difference (95% CI) | P value | |
|---|---|---|---|
| Left ventricular ejection fraction · lower with new LBBB | −2.8% (−3.4% to −2.2%) | P < 0.001 | |
| −4−202Difference (linear scale) |
Original publication
Outcomes of Patients With New Left Bundle Branch Block After TAVR: TVT Registry Insights. Circ Cardiovasc Interv. Published 2 January 2026. doi:10.1161/circinterventions.125.015441
Summarised from the published abstract; every number is checked against it