Arrhythmias & electrophysiology
Outcomes of percutaneous left atrial appendage occlusion device implantation in atrial fibrillation patients based on underlying stroke risk
Authors' conclusion
A higher CHA2DS2-VASc score was associated with an increased risk of peri-procedural complications and resource utilization after LAAO.
Study context
- Population
- AF patients undergoing percutaneous left atrial appendage occlusion (LAAO)
- Participants
- 73,795 LAAO implantations
- Exposure
- CHA2DS2-VASc score 4 and ≥5 vs 3
- Outcome
- Complications and resource utilization
Methodological detailsNational Inpatient Sample 2016-20, Data from the National Inpatient Sample, 2016-20; LAAO identified by ICD-10-CM code 02L73DK
- National Inpatient Sample 2016-20
- Data from the National Inpatient Sample, 2016-20; LAAO identified by ICD-10-CM code 02L73DK
Main finding
As reported in the abstract
Overall complications (multivariable-adjusted)
Each group vs score 3Adjusted odds ratio (95% CI)
Score 4
1.26(1.18–1.35)
Score ≥5
1.88(1.73–2.04)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Prolonged length of stay (multivariable-adjusted)Score 4vs Score 3 | 1.18 (1.11–1.25) | |
| Prolonged length of stay (multivariable-adjusted)Score ≥5vs Score 3 | 1.54 (1.44–1.66) | |
| 0.512Adjusted odds ratio (log scale) |
Share of LAAO implantations with score 4 or ≥5
- ≈63% of implantations in patients with scores 4 and ≥5
Safety
Pericardial effusion requiring intervention (crude prevalence)
- Pericardial effusion requiring intervention (crude prevalence): P < 0.01
Original publication
Outcomes of percutaneous left atrial appendage occlusion device implantation in atrial fibrillation patients based on underlying stroke risk. Europace. Published 7 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →