Cardio-oncology & otherCohort study
Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis
- Retrospective multicentre registry study
- consecutive patients
- 19 institutions
Authors' conclusion
PMA of RSIE is feasible with high procedural success. Adverse events were acceptable and largely driven by underlying RSIE.
Study context
- Population
- Patients with right-sided infective endocarditis (RSIE) undergoing percutaneous mechanical aspiration (PMA), 2014–2024
- Participants
- 256 patients · 19 institutions
- Outcome
- Composite of:
- In-hospital mortality
- New PE
- Emergency surgery
- Follow-up
- In-hospital
Main finding
As reported in the abstract
Primary endpoint
18%
Mortality
9.8%
New pulmonary embolism (PE)
8.3%
Emergency surgery
3.1%
Observational data: associations, not effects.
Secondary outcomes
Factors associated with the primary endpoint
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Shock · univariate | 2.27 (1.15–4.43) | P = 0.03 | |
| Hypoxia · univariate | 3.62 (1.83–7.17) | P < 0.001 | |
| Hypoxia · multivariate | 2.76 (1.34–5.73) | P = 0.006 | |
| 0.10.31310Odds ratio (log scale) |
Procedural success (≥70% vegetation reduction or residual ≤1 cm)
- Procedural success
- 89.4%
- Median residual vegetation size (Q1-Q3: 0.2-1.1 cm)
- 0.7 cm
Factors associated with the primary endpoint
- Worsening tricuspid regurgitation (TR) not significantly associated with the primary endpoint (univariate)
Safety
Procedure completed free from procedure-related complications
- Free from procedure-related complications
- 86.9%
In-hospital worsening TR (without baseline severe TR)
- Worsening TR
- 16.9%
Original publication
Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis. J Am Coll Cardiol. Published 27 August 2025. doi:10.1016/j.jacc.2025.06.054
Summarised from the published abstract; every number is checked against it