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Valvular & structural heart diseaseCohort study

Outcomes of Supra-Annular vs Intra-Annular Self-Expanding Valves in Valve-In-Valve Transcatheter Aortic Valve Replacement

JACC Cardiovasc IntervPublished

  • Registry-based cohort study
  • propensity score adjustment
  • multivariable logistic regression

Findings consistent after propensity score adjustment and multivariable logistic regression

Read the original article ↗

Authors' conclusion

Both SASEV and IASEV provide favorable and similar hemodynamic and clinical outcomes following ViV-TAVR.

Study context

Population
Patients undergoing Valve-in-valve Transcatheter Aortic Valve Replacement (ViV-TAVR) in the Australian Cardiovascular Outcomes Registry (ACOR)
Participants
683 patients
Exposure
SASEV vs IASEV in ViV-TAVR
  • SASEVn = 566reference
  • IASEVn = 117
Outcome
Echocardiographic (gradients, LVEF) and clinical outcomes (MACCE per VARC criteria)
Follow-up
Postprocedure and 12 months

Main finding

As reported in the abstract

Postprocedure echocardiographic findings · postprocedure
GroupDimensionless Performance Index
SASEV0.4
IASEV0.5
  • SASEV vs IASEV: P < 0.001 — Dimensionless Performance Index
Mean gradients 14.9 mm Hg vs 13.3 mm Hg
P = 0.070
Peak atrioventricular velocities 2.5 m/s vs 2.4 m/s
P = 0.073

Observational data: associations, not effects.

Further findings

MACCE · 12 months · not statistically significant

P = 0.129

Stroke · 12 months · not statistically significant

P = 0.058

Mortality · 12 months

No significant difference

Safety

Bleeding · 12 months

No significant difference

Original publication

Outcomes of Supra-Annular vs Intra-Annular Self-Expanding Valves in Valve-In-Valve Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 24 August 2026. doi:10.1016/j.jcin.2026.06.022
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it